Current Projects
Age-dependent changes in mitophagy, mitochondrial dynamics, and metabolism associated with neurodegeneration.
Mouse models of frontotemporal dementia and motor neuron disease.
Developing neuroprotective targets and exploring repurposed drugs that ameliorate aggregated TDP-43 for the treatment of AD, ALS, & FTD.
Mechanisms of cell and non-cell autonomous neurodegeneration.
Inducible TDP-43 expression and the functional relationship between memory, network connectivity, and pathology.
Mouse models of frontotemporal dementia and motor neuron disease.
Developing neuroprotective targets and exploring repurposed drugs that ameliorate aggregated TDP-43 for the treatment of AD, ALS, & FTD.
Mechanisms of cell and non-cell autonomous neurodegeneration.
Inducible TDP-43 expression and the functional relationship between memory, network connectivity, and pathology.
Publications
Davis, SA, Itaman, S, Khalid-Janney, CM, Sherard, JA, Dowell, JA, Cairns, NJ, and Gitcho, MA. “TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics” Neuroscience Letters Apr 2018
Davis, SA , Gan, KA, Dowell, JA, Cairns, NJ, and Gitcho, MA. “TDP-43 expression influences Amyloidβ plaque deposition and Tau aggregation” Neurobiology of Disease 2017 Apr 20;103:154-162.
Jackson KL, Dayton RD, Fisher-Perkins, JM, Didier PJ, Baker KC, Weimer M, Gutierrez A, Cain CD, Mathis JM, Gitcho MA, Bunnell BA, and Klein RL. Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. Journal of Medical Primatology, 2015. 44(2):66-75. PMID: 25639184
Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang Y-Z, Petrucelli L, Mathis JM, and Klein RL. Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis. Molecular Therapy 2013 Jul:21(7):1324-34
Wang, DB, Gitcho, MA, Kraemer, BC, and Klein, RL. Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis. European Journal of Neuroscience, 2011. 34(8):1179-1188 (review).
Page, T*, Gitcho, MA*, Mosaheb, S, Carter, D, Chakraverty, S, Perry, RH, Bigio, EH, Gearing, M, Ferrer, I, Goate, AM, Cairns, NJ, Thorpe, JR. FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS Proteinopathy. Journal of Molecular Neuroscience, 2011. 45(3):409-421.
Cairns, NJ, Perrin, RJ, Schmidt, RE, Gru, A, Green, KG, Carter, D, Taylor-Reinwald, L, Morris, JC, Gitcho, MA, Baloh, RH. TDP-43 proteinopathy in familial motor neuron disease with TARDBP A315T mutation: a case report. Neuropathol Appl Neurobiol. 2010. 36(7):673-679.
Wang, J, Van Damme, P, Cruchaga, C, Gitcho, MA, Vidal, JM, Seijo-Martinez, M, Wang, L, Wu, JY, Robberecht, W, and Goate, AM, Pathogenic Cysteine Mutations Affect Progranulin Function and Production of Mature Granulins. Journal of Neurochem 2010. 112(5):1305-15
Gitcho, MA*, Bigio, EH*, Mishra, M, Johnson, N, Weintraub, S, Mesulam, M, Rademakers, R, Chakraverty, S, Cruchaga, C, Morris, JC, Goate, AM, and Cairns, NJ. TARDBP 3’UTR Mutation in Autopsy-Confirmed Frontotemporal Lobar Degeneration with TARDBP Proteinopathy 2009. 118(5):633-45.
Gitcho, MA, Strider, J, Carter, D, Taylor-Reinwald, L, Forman, MS, Goate, AM, and Cairns NJ. VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death. Journal of Biological Chemistry. 2009 284(18):12384-98.
Liscic, RM,Tenenholz-Grinberg, L, Zidar, J, Gitcho, MA, and Cairns, NJ ALS and FTLD: Two faces of TDP-43 proteinopathy. European Journal of Neurology. 2008, 15(8):772-780 (review).
Gitcho MA*, Baloh RH*, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL 3rd, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, Goate AM, and Cairns NJ. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 2008. 63(4): 535-538
Most Cited Annals of Neurology Paper of the Year (2008). 545 current citations.
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, and Goate A.. Molecular Characterization of Novel Progranulin (GRN) Mutations in Frontotemporal Dementia. Human Mutation. 2008. 29(4): 512-521.
Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL 3rd, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, and Mackenzie IR. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. American Journal of Pathology. 2007. 171(1):227-40.
Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor- Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, and Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Disease and Associated Disorders. 2007. 21(1):1-7.
Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals of Neurology. 2006. 60(3):314-22.
Ju JS, Gitcho MA, Casmaer CA, Patil PB, Han DG, Spencer SA, Fisher JS. Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase. American Journal of Physiology. Cell Physiology. 2007. 292(1):564-72.
*contributed equally to this work
Davis, SA , Gan, KA, Dowell, JA, Cairns, NJ, and Gitcho, MA. “TDP-43 expression influences Amyloidβ plaque deposition and Tau aggregation” Neurobiology of Disease 2017 Apr 20;103:154-162.
Jackson KL, Dayton RD, Fisher-Perkins, JM, Didier PJ, Baker KC, Weimer M, Gutierrez A, Cain CD, Mathis JM, Gitcho MA, Bunnell BA, and Klein RL. Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. Journal of Medical Primatology, 2015. 44(2):66-75. PMID: 25639184
Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang Y-Z, Petrucelli L, Mathis JM, and Klein RL. Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis. Molecular Therapy 2013 Jul:21(7):1324-34
Wang, DB, Gitcho, MA, Kraemer, BC, and Klein, RL. Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis. European Journal of Neuroscience, 2011. 34(8):1179-1188 (review).
Page, T*, Gitcho, MA*, Mosaheb, S, Carter, D, Chakraverty, S, Perry, RH, Bigio, EH, Gearing, M, Ferrer, I, Goate, AM, Cairns, NJ, Thorpe, JR. FUS immunogold labelling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS Proteinopathy. Journal of Molecular Neuroscience, 2011. 45(3):409-421.
Cairns, NJ, Perrin, RJ, Schmidt, RE, Gru, A, Green, KG, Carter, D, Taylor-Reinwald, L, Morris, JC, Gitcho, MA, Baloh, RH. TDP-43 proteinopathy in familial motor neuron disease with TARDBP A315T mutation: a case report. Neuropathol Appl Neurobiol. 2010. 36(7):673-679.
Wang, J, Van Damme, P, Cruchaga, C, Gitcho, MA, Vidal, JM, Seijo-Martinez, M, Wang, L, Wu, JY, Robberecht, W, and Goate, AM, Pathogenic Cysteine Mutations Affect Progranulin Function and Production of Mature Granulins. Journal of Neurochem 2010. 112(5):1305-15
Gitcho, MA*, Bigio, EH*, Mishra, M, Johnson, N, Weintraub, S, Mesulam, M, Rademakers, R, Chakraverty, S, Cruchaga, C, Morris, JC, Goate, AM, and Cairns, NJ. TARDBP 3’UTR Mutation in Autopsy-Confirmed Frontotemporal Lobar Degeneration with TARDBP Proteinopathy 2009. 118(5):633-45.
Gitcho, MA, Strider, J, Carter, D, Taylor-Reinwald, L, Forman, MS, Goate, AM, and Cairns NJ. VCP Mutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death. Journal of Biological Chemistry. 2009 284(18):12384-98.
Liscic, RM,Tenenholz-Grinberg, L, Zidar, J, Gitcho, MA, and Cairns, NJ ALS and FTLD: Two faces of TDP-43 proteinopathy. European Journal of Neurology. 2008, 15(8):772-780 (review).
Gitcho MA*, Baloh RH*, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL 3rd, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, Goate AM, and Cairns NJ. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 2008. 63(4): 535-538
Most Cited Annals of Neurology Paper of the Year (2008). 545 current citations.
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, and Goate A.. Molecular Characterization of Novel Progranulin (GRN) Mutations in Frontotemporal Dementia. Human Mutation. 2008. 29(4): 512-521.
Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL 3rd, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, and Mackenzie IR. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. American Journal of Pathology. 2007. 171(1):227-40.
Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor- Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, and Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Disease and Associated Disorders. 2007. 21(1):1-7.
Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals of Neurology. 2006. 60(3):314-22.
Ju JS, Gitcho MA, Casmaer CA, Patil PB, Han DG, Spencer SA, Fisher JS. Potentiation of insulin-stimulated glucose transport by the AMP-activated protein kinase. American Journal of Physiology. Cell Physiology. 2007. 292(1):564-72.
*contributed equally to this work
